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Tip: deny your own creeps below half health to rob the enemy of gold and experience.
Pick your hero. Bots draft the other nine heroes by role: four join your side, five fight for the Scourge. Destroy their Ancient.
Right-click to move and attack. Each hero casts with its DotA hotkeys (shown on its ability buttons; Settings → Interface → Ability keys switches to Q / W / E / R), Alt + key (or Ctrl + click, or the + button) to learn a skill. An ability on a command key takes it over; the command moves to Ctrl + the key (Ctrl+B shop, Ctrl+A attack-move for Earthshaker). P pauses; Esc or F10 opens the settings (hotkeys, audio, graphics).